The put-in point is at a public boat launch in Connellsville, PA near River Mile 44. The first half of the first day's trip is in relatively shallow water with a few small rapids. The latter half is in a deeper part of the river that is easier to navigate. The latter half of the first day's trip is also one of the more scenic parts of the trip with views of Youghiogheny River Gorge.
The first day's trip ends at Layton Island, which is a large, wooded island with primitive campsites near River Mile 30. The main campsite is on the south (river left) side of the island about midway down. There are secondary campsites throughout the island. All campsites are first-come, first-serve.
The second day's trip is from Layton Island to West Newton, near River Mile 18. The first portion of the second day's trip is through shallower water, so some portage should be expected. The fastest water of the trip is near River Mile 25. There is a three-foot drop in the river here that can be negotiated safely by keeping river left.
The final stretch of the trip is a pleasant trip to West Newton that passes through Cedar Creek Park at River Mile 22.
The first day's trip can be done in about eight hours with a couple of stops for lunch, fishing, or swimming. It's advisable to get to Layton Island before dark since there is some poison ivy on the island, and it will take some bushwhacking to find the secondary campsites if the main campsite is taken. The second day's trip can be done in about six hours with a short stop for lunch.